Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)
نویسندگان
چکیده
منابع مشابه
Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS).
The present study reports elevated levels of endotoxin/lipopolysaccharide (LPS) concentrations in plasma from patients with sporadic amyotrophic lateral sclerosis (sALS) and Alzheimer's (AD) as compared to healthy controls. Levels of plasma LPS showed a significant positive correlation with degree of blood monocyte/macrophage activation in disease groups and was most elevated in patients with a...
متن کاملEvidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS).
Sporadic amyotrophic lateral sclerosis (sALS) is a progressive neuroinflammatory disease of spinal cord motor neurons of unclear etiology. Blood from 38 patients with sALS, 28 aged-match controls, and 25 Alzheimer's disease (AD) patients were evaluated and activated monocyte/macrophages were observed in all patients with sALS and AD; the degree of activation was directly related to the rate of ...
متن کاملSporadic amyotrophic lateral sclerosis
This article briefly describes the already known clinical features and pathogenic mechanisms underlying sporadic amyotrophic lateral sclerosis, namely excitoxicity, oxidative stress, protein damage, inflammation, genetic abnormalities and neuronal death. Thereafter, it puts forward the hypothesis that astrocytes may be the cells which serve as targets for the harmful action of a still unknown e...
متن کاملGene expression profiling in peripheral blood mononuclear cells from patients with sporadic amyotrophic lateral sclerosis (sALS).
The aim of this study was to identify gene expression profiles in peripheral blood mononuclear cells (PBMCs) from sporadic amyotrophic lateral sclerosis (sALS) patients to gain insights into the pathogenesis of ALS. We found that upregulation of LPS/TLR4-signaling associated genes was observed in the PMBCs from sALS patients after short-term cultivation, and that elevated levels of gene express...
متن کاملSporadic amyotrophic lateral sclerosis. A clinical analysis
Objective. To illustrate that sporadic amyotrophic lateral sclerosis (ALS) may be caused by ischemia in the intraparenchymal territory of the anterior spinal artery (ASA) and/or anterior-ventral spinal arteries (AVSAs). Case report. A 56-year-old woman presented clinical data of spinal and bulbar forms of ALS. Previously she was attended in several neurological centers. Results. In 2002 the pat...
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ژورنال
عنوان ژورنال: Journal of Neuroimmunology
سال: 2009
ISSN: 0165-5728
DOI: 10.1016/j.jneuroim.2008.09.017